Psychiatry in Action Lab

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Wolpe N, Chen S, Kirkpatrick B, Jones PB, Jenkins C, Cardinal RN, Fernandez-Egea E (in press). Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study. Br J Psychiatry. 10:1-3. [full study]

King DLO, Henson RN, Kievit R, Wolpe N, Brayne C, Tyler LK, Rowe JB; Cam-CAN; Tsvetanov KA. Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities. Sci Rep. 13:978. [full study]


Wolpe N, Hezemans FH, Rae CL, Zhang J, Rowe JB. The pre-supplementary motor area achieves inhibitory control by modulating response thresholds. Cortex. 152:98-108. [full study]

Fernandez-Egea E, Wolpe N. Is it time to change the term negative symptoms? Eur Neuropsychopharmacol. 59:7-8. [link to paper]

Hezemans FH, Wolpe N, O'Callaghan C, Ye R, Rua C, Jones PS, Murley AG, Holland N, Regenthal R, Tsvetanov KA, Barker RA, Williams-Gray CH, Robbins TW, Passamonti L, Rowe JB. Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes. PLoS Comput Biol. 18:e1010079. [link to paper]

Tomassini A, Hezemans FH, Ye R, Tsvetanov KA, Wolpe N, Rowe JB. Prefrontal Cortical Connectivity Mediates Locus Coeruleus Noradrenergic Regulation of Inhibitory Control in Older Adults. J Neurosci. 42:3484-3493. [full study]


O'Callaghan C, Hezemans FH, Ye R, Rua C, Jones PS, Murley AG, Holland N, Regenthal R, Tsvetanov KA, Wolpe N, Barker RA, Williams-Gray CH, Robbins TW, Passamonti L, Rowe JB. Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease. Brain. 144:2513-2526. [full study]


Wolpe N, Hezemans FH, Rowe JB (2020). Alien limb syndrome: A Bayesian account of unwanted actions. Cortex 127: 29-41. [full study]

Lewis-Smith D, Wolpe N*, Gosh BCP, Rowe JB (2020). Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia. *Joint first author. Journal of Neurology. 267: 1147–1157. [full study]

Hezemans FH, Wolpe N, Rowe JB (2020). Apathy is associated with reduced precision of prior beliefs about action outcomes. Journal of Experimental Psychology: General. 149: 1767-1777. [full study]

Wolpe N, Ingram JN, Tsvetanov K, Henson RN, Wolpert DM, Cam-CAN, Rowe JB (2020). Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory. Neurobiology of Ageing. 90: 13-23. [full study]

Featured article: Learning new tricks

Man performing a motor task. Difficulties in learning new motor skills in old age are related to changes in 'explicit' learning systems.

As we grow older, it becomes more difficult to learn new skills. This holds true for skills that are purely “mental”, like learning a new language, but also for motor skills that involve movement, like learning how to ride a bike. Neuroscience research has classically separated these two types of learning into: 1) ‘explicit’ learning, which is considered a conscious and deliberate process of attaining new information, and which relies on a brain structure called the hippocampus. 2) ‘implicit’ learning, which happens automatically without conscious awareness, and which depends on a brain structure called the cerebellum. Research has shown that as we grow older, our explicit learning is not as good as it used to be when we were younger. By contrast, implicit learning remains largely unaffected by our age. However, these observations could not explain why in old age it is similarly difficult to learn both mental and motor skills. A new Cam-CAN study shows that as we get older, motor skill learning shifts to rely more on explicit learning and its brain structure. Changes in the hippocampus, but not in the cerebellum, explain why for many people, this type of learning gets more difficult as they get older. While the reason for this shift is unclear, it might help us design new learning methods for older people that will encourage them to use their intact implicit learning, so that they can easily continue to learn new tricks.

Full details in:

Wolpe N, Ingram JN, Tsvetanov KA, Henson RN, Wolpert DM; Cam-CAN, Rowe JB (2020). Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory. Neurobiology of Aging. 90:13-23. doi: 10.1016/j. neurobiolaging.2020.02.016.


Wolpe N, Zhang Z, Nombela C, Ingram JN, Cam-CAN, Wolpert DM, Rowe JB (2018). Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose. Scientific Reports 8: 15643. [full text]

Tsvetanov K, Ye Z, Hughes L, Samu D, Treder M, Wolpe N, Tyler LK, Cam-CAN, Rowe JB (2018). Activity and connectivity differences underlying inhibitory control across the adult lifespan. Journal of Neuroscience 38: 7887-7900. [full text]


Wolpe N, Ingram JN, Tsvetanov K, Geerligs L, Kievit RA, Henson RN, Wolpert DM, Cam-CAN, Rowe JB (2016). Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature Communications 7: 13034. [full text]

Zhang Z, Nombela C, Wolpe N, Barker RA, Rowe JB (2016). Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's disease. Movement Disorders 31: 1163-1172. [full text]


Wolpe N, Nombela C, Rowe JB (2015). Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease. Frontiers in Psychology 6: 1514. [full text]


Wolpe N, Moore JW, Rae C, Rittman T, Altena E, Haggard P, Rowe JB (2014). The medial frontal-prefrontal network for altered awareness of action in corticobasal syndrome. Brain 137: 208-220. [full text]

Wolpe N, Rowe JB (2014). Beyond the “urge to move”: objective measures for the study of agency in the post-Libet era. Frontiers in Human Neuroscience 8: 450. [full text]

Wolpe N, Wolpert DM, Rowe JB (2014). Seeing what you want to see: priors for one’s own actions represent exaggerated expectations of success. Frontiers in Behavioral Neuroscience 8: 232. [full text]


Wolpe N, Haggard P, Siebner HR, Rowe JB (2013). Cue integration and the perception of action in intentional binding. Experimental Brain Research 229: 467-474. [full text]


Galli G, Wolpe N, Otten LJ (2011). Sex differences in the use of anticipatory brain activity to encode emotional events. Journal of Neuroscience 31: 12364-12370. [full text]